When vein problems are left untreated, it can lead to long term problems. Patients can have swelling and pain. Complicated cases can progress to poor wound healing and ulceration. These medical conditions need treatment. There can be several potential abnormalities that can lead to chronic venous disease. The first step is determining the underlying cause. Your medical history may offer some clues. Patients with a history of blood clots in their legs (DVT) or a long history of varicose veins can develop chronic venous disease.